Name | Nimesulide d5 |
Synonyms | Nimesulide d5 [2H5]-Nimesulide N-[4-nitro-2-(2,3,4,5,6-pentadeuteriophenoxy)phenyl]methanesulfonamide |
CAS | 1330180-22-7 |
Molecular Formula | C13H7D5N2O5S |
Molar Mass | 313.34058889 |
Storage Condition | -20°C,干燥,密封 |
biological activity | Nimesulide D5 is a deuterated compound of Ethacrynic acid. Nimesulide is a selective COX-2 inhibitor with a time-dependent inhibition with an IC50 of 70 nM-70 μm, however, the effect on COX-1 was weak (IC50 >100 μm). Nimesulide has anti-inflammatory, analgesic and antipyretic effects. |